Oral Administration of Zolpidem Tartrate in an Abuse-deterrent Formulation Versus an Immediate Release Formulation in Beagle Dogs
Keywords:In vivo, Zolpidem, abuse-deterrent formulation, HPLC
Objective: The continuing rise of prescription drug abuse has greatly necessitated the development of an abuse-deterrent formulation. Geopolymers are a promising base for drug design as they allow for tuneable drug release and possess superior physical and chemical properties compared with conventional pharmaceutical excipients.
Methods: Geopolymer pellets containing zolpidem tartrate were administrated orally to beagle dogs as a controlled-release formulation with the commercial immediate-release product, Stilnoct® tablets, as the control.
Results: The administration of zolpidem tartrate as immediate-release tablets demonstrated an elevated immediate release plasma profile and the zolpidem tartrate in the geopolymers demonstrated a controlled-release plasma profile. The pharmacokinetic analysis demonstrated that immediate-release tablet administration generated much higher plasma concentration when compared with geopolymer pellets administration for zolpidem tartrate. On the other hand, the geopolymer formulation prolonged the time of drug release.
Conclusion: Oral administration of zolpidem tartrate in geopolymer pellets demonstrated a controlled-release plasma profile.
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